Interferon-β lipofection II. Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-β gene transfer to human tumor cells
نویسندگان
چکیده
منابع مشابه
Novel interferon-β-induced gene expression in peripheral blood cells.
Type I IFNs are used for treating viral, neoplastic, and inflammatory disorders. The protein products encoded by IFN-stimulated genes (ISGs) likely mediate clinical effects of IFN in patients. Macroarray assays, used for studying ISG induction in IFN-treated patients, comprise genes identified predominantly through analysis of long-term cell lines. To discover genes induced selectively by IFN-β...
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hematoma caused by insulin injections. Clin Nucl Med 1990; 15: 539–541 2. Yoshida T, Harayama T, Kusunoki C et al. A case of type 2 diabetes mellitus with a giant subcutaneous hematoma caused by rough insulin injection. J Japan Diab Soc 2008; 51: 929–932 3. Kahara T, Kawara S, Shimizu A et al. Subcutaneous hematoma due to frequent insulin injections in a single site. Intern Med 2004; 43: 148–14...
متن کاملOverexpression of Recombinant Human Beta Interferon (rhINF-β) in Periplasmic Space of Escherichia coli
Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks and bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon ...
متن کاملStochastic Expression of the Interferon-β Gene
Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction of the infected cells produce IFN. However, the mechanisms responsible for this stochastic expression are poorly understood. Here we report an in depth analysis of IFN-expr...
متن کاملOverexpression of Recombinant Human Beta Interferon (rhINF-β) in Periplasmic Space of Escherichia coli
Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks and bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon ...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2012
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2012.19